Watch Intently (2)pentobarbital will lower the extent or impact of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Strong CYP3A4 inducers could minimize suvorexant efficacy; if elevated suvorexant dose essential, usually do not exceed 20 mg/daypentobarbital will minimize the extent or impact of ibuprofen by